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Depression can be overwhelming, especially when you've already tried multiple medications without feeling true relief. Many adults living with treatment-resistant depression or major depressive disorder with suicidal thoughts often feel discouraged, stuck, or unsure of what to try next. These symptoms can affect quality of life, relationships, energy, and ability to function day to day.
One of the most promising options available today is Spravato® (esketamine). This FDA-approved nasal spray is designed for adults who need a different kind of relief—something that works through a new pathway in the brain and may help faster than traditional medications. Spravato is administered here in our office under the care of our experienced medical team, giving you a safe and supportive environment throughout the entire process.
If you've been searching for a treatment that offers hope after other medications have fallen short, Spravato may provide the breakthrough you've been waiting for. Our goal at Impireum is to help you understand your options and feel confident about the next steps in your mental health journey.
Spravato is an FDA-approved medication that contains esketamine. Unlike traditional antidepressants, which work on serotonin, norepinephrine, or dopamine, Spravato targets the glutamate system, which is the brain’s most abundant neurotransmitter network. Glutamate plays an essential role in learning, memory, and emotional regulation. When its pathways are disrupted, depression can become harder to treat with standard medications.
Spravato is delivered through a nasal spray device that you self-administer under medical supervision. Because it affects the brain differently, many patients who have not responded to other antidepressants may benefit from this treatment.
Spravato is recommended for adults with:
Most antidepressants take several weeks to build up in the body and begin working. In contrast, Spravato interacts with glutamate receptors almost immediately. Many patients report noticeable changes in their mood, thinking, or energy level early in their treatment series.
Scientists believe that Spravato helps:
Starting a new type of treatment can feel intimidating, especially if you've never used a nasal spray medication before. At Impireum, we guide you through every step so you always know what to expect.
Before your session, we check your vital signs, discuss how you've been feeling, and review your treatment plan. Your provider will explain the dose and walk you through how the nasal spray works. You administer the medication yourself under our supervision, ensuring you feel comfortable and informed.
After you take the medication, you’ll remain in a comfortable, private treatment room for two hours. These rooms are designed to help you relax—with soft lighting, cozy seating, and a peaceful atmosphere. During this time, our team closely monitors you to ensure your safety and comfort. Because Spravato can cause temporary feelings of dissociation, dizziness, or drowsiness, you’ll always have support nearby.
Some patients choose to rest quietly, listen to calming music, or simply take time to relax. The goal is to let your body adjust while we observe how you respond.
Once the two-hour monitoring period is complete, we check your vitals again, review how you're feeling, and make sure you're stable before you leave. Because of the temporary effects on alertness and coordination, you'll need someone to drive you home. Many clients report feeling more tired than usual for the rest of the day, so we recommend keeping your schedule light.
You can return to most normal activities the following day, and your provider will check in regularly to track how your symptoms change over time.
Spravato® is designed for adults who need a different kind of support in their depression treatment journey. Many people come to this option after trying multiple medications without the relief they hoped for. Others are facing more severe symptoms and need a treatment that may work more quickly than traditional antidepressants. Spravato targets a different pathway in the brain, helping create changes in mood in a shorter period of time.
Impireum is committed towards carefully looking at each person's full story before recommending Spravato. Your symptoms, treatment history, safety needs, and overall health help us determine whether this medication is the right fit. Our team is here to guide you through every step so you feel supported, informed, and confident as you explore whether Spravato could be a meaningful part of your care.
Treatment-resistant depression can feel like an endless cycle of trying new medications, adjusting doses, and waiting weeks to see if anything changes. Many people experience ongoing sadness, low motivation, difficulty concentrating, sleep issues, and emotional numbness. When multiple antidepressants have failed, it can be easy to lose hope.
Spravato is specifically designed for people in this situation. Its unique mechanism provides an option outside the traditional medication approach, offering a new possibility when other treatments haven't worked.
For adults experiencing suicidal thoughts as part of major depressive disorder, daily life can feel heavy, isolating, and difficult to manage. During these moments, finding a treatment that offers relief sooner rather than later can make a meaningful difference.
Spravato may help provide improvement more quickly than traditional medications, giving individuals a chance to feel more stable, grounded, and in control as they move through a challenging period. By targeting a different pathway in the brain, it may help ease the intensity of suicidal thoughts and support clearer thinking as treatment progresses.
Depression often steals energy, motivation, and clarity. For many people, the slow response time of traditional antidepressants adds another layer of frustration. These medications can take several weeks before any shifts in mood or motivation appear, which can feel discouraging when symptoms are already weighing heavily on daily life.
Spravato offers a different path forward for individuals who need a treatment option that may work sooner. Because Spravato acts on the brain's glutamate system rather than the serotonin pathway targeted by most standard medications, it has the potential to create changes more quickly. Some clients begin noticing early improvements during the first phase of treatment, such as feeling more emotionally steady, more present, or more capable of engaging in therapy and daily routines.
These early shifts can give people a renewed sense of momentum and hope, helping them stay committed to their overall mental health plan.
While every person responds differently, the possibility of faster relief can make a meaningful difference for individuals who feel stuck or exhausted by long treatment timelines. At Impireum, our team explains what to expect, monitors your progress closely, and adjusts your care as needed so you can move toward healing with confidence and support.
Before starting Spravato, our clinicians perform a thorough evaluation. This allows us to determine whether it's safe, appropriate, and likely to help your specific symptoms. During your evaluation, we look at:
No two people experience depression in exactly the same way, so your Spravato plan should reflect your unique needs. At Impireum, your treatment is personalized from the very beginning. Throughout your sessions, your provider pays close attention to how your symptoms change, how you tolerate the medication, and whether adjustments need to be made. This might include modifying the frequency of sessions, checking in more often, or combining Spravato with other forms of support that enhance its benefits.
Your provider also helps track improvements in mood, energy, concentration, and overall stability. Depression can shift over time, and having a team that adapts your plan makes the experience safer and more effective.
Spravato works best when paired with a complete mental health plan. While the medication targets your brain's glutamate system, therapy helps you understand patterns, build new coping skills, and process experiences that may have contributed to your symptoms. Psychiatry ensures that your medication plan remains aligned with your long-term goals.
Impireum's integrative approach allows all of these elements to work together. Our clinicians communicate with one another to ensure that your care is consistent, organized, and designed to give you the best possible results. Instead of juggling multiple providers across different offices, you have a coordinated team supporting you at every step.
Because depression affects more than your mood alone, mind-body balance is an important part of recovery. During your Spravato treatment series, our wellness services can help reduce stress, improve sleep, and support overall emotional health. Clients often benefit from grounding practices, relaxation therapies, and supportive treatments that create a calmer physical and mental state.
This combined care model helps you feel more centered throughout the process. When your body relaxes and your mind feels supported, it's easier to maintain momentum and experience the full benefits of your treatment.
Impireum understands the challenges of living with depression, especially when multiple treatments have failed. We have extensive experience supporting clients through Spravato programs and offer compassionate care designed to help you feel understood and supported. Our team takes time to listen so your plan reflects your goals and needs.
What makes Impireum different is the way our services work together. With psychiatry, therapy, and wellness treatments available in one place, you receive care that considers your whole self—not just your symptoms. This integrated model helps you progress more smoothly and gives you space to heal from multiple angles.
When Spravato is combined with therapy and ongoing psychiatric support, clients often experience stronger, longer-lasting improvements. Everything you need is under one roof, making your mental health journey more convenient and cohesive.
Depression can already make life feel heavy, so your treatment environment should feel calm and safe. Our Spravato rooms offer a peaceful space where you can settle in, relax, and let your body adjust to the medication. With soft lighting, comfortable seating, and caring staff nearby, your session becomes an opportunity to breathe and reset.
Our goal is to make every visit as smooth and comfortable as possible. When you feel supported, it becomes easier to engage fully in your treatment and move toward meaningful change.
If depression has made you feel stuck or if your current medications aren't providing the relief you need, Spravato may offer a new way forward. At Impireum, we're here to guide you through the process, answer your questions, and help you feel confident about your options.
Your path to healing does not have to feel overwhelming. Our team is ready to support you with compassion, expertise, and a comprehensive plan that fits your life. Reach out to schedule your evaluation and start exploring whether Spravato can help you rediscover clarity, stability, and hope.